In recent years, the country has paid more and more attention to the research and scientific research in the field of biosafety and disease control. After the worldwide outbreak of Covid-19, SARS, avian flu, mad cow disease (BSE) and other malignant and highly infectious diseases, this kind of research has become the focus of attention from all walks of life.In order to better serve for this kind of scientific research work, the state made the corresponding "Laboratory Biosafety General Requirements" (GB19489-2007) to standardize and improve the design, construction and management of biosafety laboratories. In this "Requirement", the air filtration system used in the biosafety laboratory is specified in detail, and it is proposed that "if the exhaust HEPA is installed in the equipment layer (room) outside the laboratory, it must be equipped with the conditions for safe replacement by using air-tight bags".

Bag in and bag out filter(BIBO) is similar to the composition of modular air conditioning unit, it is assembled in the bag in/bag out Housing (Bibo Housing) after combination of different functional unit according to user’s requirements. Common functional units include: Pre-filter, High Efficiency Particle Filter, High Efficiency Gas Adsorption Filter (HEGA), Precision Scan test Sections, etc.

Under normal circumstances, the filter of the bag in/bag out consists of two parts, filter unit and detection unit. The most simple filtration unit contains only efficient particle filter, if the air is not filtered before entering the BIBO system, pre-filters must be used to protect the efficient particle filter. If the inlet air need adsorption filtration, then high efficiency air adsorption filter is needed; Detection unit refers to an automatic (or manual) fine scanning detection device.

In addition to the above main components, there are some supporting equipment on the filter box of BIBO system, such as pressure gauge, pressure hole, quick connection port, etc.. Micro high efficiency particle filters are used between these components and the BIBO housing, to ensure good isolation effect from the outside. Bag in and bag out filter and the air tight isolation dampers constitute a complete air filtration and isolation system, which is called "Containment Systems" in North America.